Rat Klotho beta / KLB Protein, His Tag
Rat Klotho beta, His Tag (KLB-R52H6) is expressed from human 293 cells (HEK293) . It contains AA Phe 53 - Pro 994 (Accession # D3Z8T6-1) .
Product Specifications
Background
KLB (Klotho Beta) is a Protein Coding gene. Among its related pathways are RET signaling and HIV Life Cycle. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and fibroblast growth factor binding. An important paralog of this gene is KL. Klotho Beta is a regulator in multiple metabolic processes, while its role in cancer remains unclear. We found the expression of βKlotho was down-regulated in human hepatocellular carcinoma tissues compared with that in paired adjacent non-tumourous liver tissues. Hepatoma cells also showed decreased expression of βKlotho compared with normal hepatocyte cells. Reintroduction of βKlotho into hepatoma cells inhibited their proliferation.
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 110.5 kDa. The protein migrates as 130-145 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
D3Z8T6-1
Expression Region
Phe 53 - Pro 994
Host
HEK293
Target
Klotho beta
Conjugation
Unconjugated
Tag
C-10xHis
Source
Rat
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
90%
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
110.5 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/KLB-R52H6.pdf
Species
Rat
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