Maresin 1-d5

Maresin 1-d5 is the deuterium labeled Maresin 1. Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].

Product Specifications

Product Name Alternative

CC 122,CC 122 (hydrochloride)

UNSPSC

12352211

Target

Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

O[C@H](/C=C\C=C\C=C\[C@@H](C/C=C\CCC(O)=O)O)C/C=C\C/C=C\C([2H])(C([2H])([2H])[2H])[2H]

Molecular Formula

C22H27D5O4

Molecular Weight

365.52

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Markus V Olsen, et al. Maresin 1, a Specialized Proresolving Mediator, Stimulates Intracellular [Ca 2+ ] and Secretion in Conjunctival Goblet Cells. J Cell Physiol. 2020 Jun 8.|[3]Macrophage Proresolving Mediator Maresin 1 Stimulates Tissue Regeneration and Controls Pain|[4]Rodrigo Marcon, et al. Maresin 1, a Proresolving Lipid Mediator Derived From omega-3 Polyunsaturated Fatty Acids, Exerts Protective Actions in Murine Models of Colitis. J Immunol. 2013 Oct 15;191 (8) :4288-98.