S1R agonist 2
S1R agonist 2 (Compound 8b) is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1].
Product Specifications
CAS Number
[150085-21-5]
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s1r-agonist-2.html
Purity
98.0
Solubility
DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C1(OCCCN2CCC(CC2)CC3=CC=CC=C3)=CC=CC=C1
Molecular Formula
C21H27NO
Molecular Weight
309.45
References & Citations
[1]Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Sigma 1 Receptor; Sigma 2 Receptor
Available Sizes
Curated Selection
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