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RB-005

RB-005 is a selective inhibitor of sphingosine kinase 1 (SK1) (IC50=3.6 µM), with weaker inhibition of another isoenzyme, SK2. The selective inhibition of RB-005 helps to distinguish the biological functions and roles of SK1 and SK2, which can be used in the study of inflammatory diseases and cancer[1].

Product Specifications

CAS Number

1425049-20-2

UNSPSC

12352005

Target

SphK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rb-005.html

Smiles

CCCCCCCCC1=CC=C(CCN2CCC(O)CC2)C=C1

Molecular Formula

C21H35NO

Molecular Weight

317.51

References & Citations

[1]Baek D J, et al. Structure–activity relationships and molecular modeling of sphingosine kinase inhibitors[J]. Journal of medicinal chemistry, 2013, 56 (22) : 9310-9327.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SphK1

Frequently Asked Questions

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