FAM-DEALA-Hyp-YIPD
FAM-DEALA-Hyp-YIPD is a fluorescent HIF-1α peptide, with the Kd of 180-560 nM. FAM-DEALA-Hyp-YIPD can be used to assess VHL binding in Fluorescence Polarization (FP) displacement assay, and evaluate the effect of VHL binding on degradation activity[1].
Product Specifications
UNSPSC
12352209
Target
Others
Type
Peptides
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/fam-deala-hyp-yipd.html
Purity
99.39
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC(C1=CC2=C(C=C1)C3(C4=CC=C(O)C=C4OC5=C3C=CC(O)=C5)OC2=O)=O)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N6[C@H](C(N[C@H](C(N[C@H](C(N7[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CCC7)=O)[C@H](CC)C)=O)CC8=CC=C(O)C=C8)=O)C[C@H](C6)O)=O)C)=O)CC(C)C)=O)C)=O)CCC(O)=O
Molecular Formula
C71H84N10O25
Molecular Weight
1477.48
References & Citations
[1]Buckley DL, et al. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction. J Am Chem Soc. 2012;134 (10) :4465-4468.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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