Anti-osteoporosis agent-11
Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. Anti-osteoporosis agent-11 has the most significant inhibitory effect on osteoclast differentiation, with an IC50 value of 0.36 μM. In addition, Anti-osteoporosis agent-11 inhibits osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking rankl-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways[1].
Product Specifications
CAS Number
2869099-50-1
UNSPSC
12352005
Target
NF-κB; p38 MAPK; RANKL/RANK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; NF-κB
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/anti-osteoporosis-agent-11.html
Smiles
O=C1C([Se]C2=CC=CC=C2)=C(C(N1CC3=CC=CC=C3)=O)[Se]C4=CC=CC=C4
Molecular Formula
C23H17NO2Se2
Molecular Weight
497.31
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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