NU-7163
NU-7163 is an ATP-competitive DNA-PK inhibitor (IC50=0.19 μM; Ki=24 nM) . NU-7163 enhances the cytotoxicity of ionizing radiation against the HeLa human tumor cell line in vitro[1].
Product Specifications
CAS Number
503468-03-9
UNSPSC
12352005
Target
DNA-PK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nu-7163.html
Smiles
O=C1C=C(N2CCOC(C2)C)OC3=C1C=CC4=C3C=CC=C4
Molecular Formula
C18H17NO3
Molecular Weight
295.33
References & Citations
[1]Griffin R J, et al. Selective benzopyranone and pyrimido [2, 1-a] isoquinolin-4-one inhibitors of dna-dependent protein kinase: synthesis, structure− activity studies, and radiosensitization of a human tumor cell line in vitro[J]. Journal of medicinal chemistry, 2005, 48 (2) : 569-585.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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