Linaprazan glurate
Linaprazan glurate (X842) is an orally atcive prodrug of Linaprazan with a potent and prolonged inhibitory effect on gastric acid secretion. Linaprazan glurate is rapidly transformed by enzymatic cleavage into its active metabolite, linaprazan. Linaprazan glurate is a potassium-competitive acid blocker. Linaprazan glurate selectively inhibites acid formation from gastric H⁺/K⁺-ATPase in a potassium-dependent manner (IC50 = 436.2 nM). Linaprazan glurate can be used for the studies of erosive esophagitis (EE)[2].
Product Specifications
CAS Number
1228559-81-6
Product Name Alternative
X842
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Drug Intermediate; Proton Pump
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Others
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/linaprazan-glurate.html
Concentration
10mM
Purity
99.65
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CCCC(OCCNC(C1=CN2C(C)=C(C)N=C2C(NCC3=C(C)C=CC=C3C)=C1)=O)=O)O
Molecular Formula
C26H32N4O5
Molecular Weight
480.56
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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