Lapaquistat
Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of Lapaquistat acetate. Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy[1].
Product Specifications
CAS Number
189059-71-0
Product Name Alternative
T-91485
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Drug Metabolite; Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lapaquistat.html
Purity
99.81
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(O)CC1CCN(C(C[C@@H]2C(N(CC(C)(C)CO)C3=CC=C(Cl)C=C3[C@@H](C4=CC=CC(OC)=C4OC)O2)=O)=O)CC1
Molecular Formula
C31H39ClN2O8
Molecular Weight
603.10
Precautions
H302, H315, H319
References & Citations
[1]Nishimoto T, et al. Comparing myotoxic effects of squalene synthase inhibitor, T-91485, and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors in human myocytes. Biochem Pharmacol. 2003 Dec 1;66 (11) :2133-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
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