Human GCGR / Glucagon receptor Protein, Fc Tag, low Endotoxin (MALS verified)

The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of type 2 diabetes mellitus (T2DM) . The ever increasing prevalence of type 2 diabetes mellitus in the developed and developing nations calls for the introduction of new and more effective treatments. Glucagon receptor (GCGR) antagonists are highly validated in preclinical models of T2DM and thus have the potential to be developed as a new therapy.

Product Specifications

Background

Specifications

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 39.5 kDa. The protein migrates as 52-62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

P47871-1

Expression Region

Ala 26 - Lys 136

Host

CHO

Target

GCGR

Conjugation

Unconjugated

Tag

C-Fc

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

0.01 EU per μg

Purity

95%

Bioactivity

Immobilized Human GCGR Protein, Fc Tag (Cat. No. GCR-H53H3) at 1 μg/mL (100 μL/well) can bind Anti-GCGR Antibody，Human IgG4 with a linear range of 0.5-16 ng/mL (QC tested).