KHKI-01215

KHKI-01215 is an inhibitor for NUAK2 with an IC50 of 0.052 μM. KHKI-01215 inhibits the proliferation of cancer cell SW480 with an IC50 of 3.16 μM, induces apoptosis in SW480. KHKI-01215 inhibits the YAP signaling pathway[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; YAP

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/khki-01215.html

Purity

98.78

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

FC(C1=CC(NC2=NC=C(I)C(OC3=CC=CC(N(C)C)=C3)=N2)=CC=C1N4CCN(C)CC4)(F)F

Molecular Formula

C24H26F3IN6O

Molecular Weight

598.40

References & Citations

[1]Lee SH, et al., NUAK2 Inhibitors, KHKI-01128 and KHKI-01215, Exhibit Potent Anticancer Activity Against SW480 Colorectal Cancer Cells. Anticancer Res. 2024 Jul;44 (7) :2909-2919.