KHKI-01215
KHKI-01215 is an inhibitor for NUAK2 with an IC50 of 0.052 μM. KHKI-01215 inhibits the proliferation of cancer cell SW480 with an IC50 of 3.16 μM, induces apoptosis in SW480. KHKI-01215 inhibits the YAP signaling pathway[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; YAP
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/khki-01215.html
Purity
98.78
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC(C1=CC(NC2=NC=C(I)C(OC3=CC=CC(N(C)C)=C3)=N2)=CC=C1N4CCN(C)CC4)(F)F
Molecular Formula
C24H26F3IN6O
Molecular Weight
598.40
References & Citations
[1]Lee SH, et al., NUAK2 Inhibitors, KHKI-01128 and KHKI-01215, Exhibit Potent Anticancer Activity Against SW480 Colorectal Cancer Cells. Anticancer Res. 2024 Jul;44 (7) :2909-2919.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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