DMP 777
Product Specifications
UNSPSC Description
DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
Target Antigen
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/DMP-777.html
Purity
99.75
Solubility
DMSO : 38.33 mg/mL (ultrasonic)
Smiles
CCC[C@H](C1=CC2=C(C=C1)OCO2)NC(N3[C@H](C(CC)(C3=O)CC)OC4=CC=C(C=C4)C(N5CCN(CC5)C)=O)=O
Molecular Weight
564.67
References & Citations
[1]Ogawa M, et al. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Dig Dis Sci. 2006 Mar;51(3):431-9.|[2]Zagrobelny J, et al. Separation of the four stereoisomers of a potent inhibitor (L-694,458) of human leukocyte elastase and its determination in human plasma using achiral/chiral chromatography with column switching. J Pharm Biomed Anal. 1998 Sep 1;17(6-7|[3]Weis VG, et al. Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 23:ajpgi.00326.2016
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-75957/DMP-777-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-75957/DMP-777-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
157341-41-8
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Monoclonal Histone H3 [p Ser10] Antibody (RM162) [Janelia Fluor 646]](https://cdn.genprice.uk/genprice/genprice2.png)
NBP3-26022JF646 0.1 mL
Rabbit Monoclonal Histone H3 [p Ser10] Antibody (RM162) [Janelia Fluor 646]
Ask
View Details 
MR219922L4V 200 µL
Defb29 (NM_001001444) Mouse Tagged ORF Clone Lentiviral Particle
Ask
View Details