DMP 777

DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.

Product Specifications

CAS Number

[157341-41-8]

Product Name Alternative

L-694458

UNSPSC

12352005

Target

Elastase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/DMP-777.html

Purity

99.82

Solubility

DMSO : 38.33 mg/mL (ultrasonic)

Smiles

CCC[C@H](C1=CC2=C(C=C1)OCO2)NC(N3[C@H](C(CC)(C3=O)CC)OC4=CC=C(C=C4)C(N5CCN(CC5)C)=O)=O

Molecular Formula

C31H40N4O6

Molecular Weight

564.67

References & Citations

[1]Ogawa M, et al. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Dig Dis Sci. 2006 Mar;51 (3) :431-9.|[2]Zagrobelny J, et al. Separation of the four stereoisomers of a potent inhibitor (L-694,458) of human leukocyte elastase and its determination in human plasma using achiral/chiral chromatography with column switching. J Pharm Biomed Anal. 1998 Sep 1;17 (6-7|[3]Weis VG, et al. Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 23:ajpgi.00326.2016