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IRAK4 ligand-12

IRAK4 ligand-12 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs) . IRAK4 ligand-12 can be used for the synthesis of KTX-951 (HY-148290) [1].

Product Specifications

CAS Number

[2573304-97-7]

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/irak4-ligand-12.html

Smiles

O=C(C1=CC=CC(C(F)(F)C)=N1)NC2=CC3=CN([C@@H]4CC[C@H](CC4)C=O)N=C3C=C2OC

Molecular Formula

C23H24F2N4O3

Molecular Weight

442.46

References & Citations

[1]Walker D H, et al. Degraders targeting both IRAK4 and IMiD substrates show combinatorial effects leading to broader activity with durable and complete regressions in MYD88 mutant lymphoma xenografts in vivo. Cancer Research, 2020, 80 (16_Supplement) : 5222-5222.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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