IRAK4 ligand-12
IRAK4 ligand-12 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs) . IRAK4 ligand-12 can be used for the synthesis of KTX-951 (HY-148290) [1].
Product Specifications
CAS Number
[2573304-97-7]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/irak4-ligand-12.html
Smiles
O=C(C1=CC=CC(C(F)(F)C)=N1)NC2=CC3=CN([C@@H]4CC[C@H](CC4)C=O)N=C3C=C2OC
Molecular Formula
C23H24F2N4O3
Molecular Weight
442.46
References & Citations
[1]Walker D H, et al. Degraders targeting both IRAK4 and IMiD substrates show combinatorial effects leading to broader activity with durable and complete regressions in MYD88 mutant lymphoma xenografts in vivo. Cancer Research, 2020, 80 (16_Supplement) : 5222-5222.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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