SHP2-IN-34

SHP2-IN-34 (compound A8) is a phenyl urea SHP2 inhibitor with anti-cancer activity. SHP2-IN-34 significantly suppresses tumor growth in CT26 mouse model[1].

Product Specifications

CAS Number

[2924065-12-1]

UNSPSC

12352005

Target

SHP2

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shp2-in-34.html

Smiles

O=C(NC1=C(Cl)C(SC2=NC=C(N3CCC(C)(CC3)N)N=C2N)=CC=C1)NC4=CC(Cl)=CC=C4

Molecular Formula

C23H25Cl2N7OS

Molecular Weight

518.46

References & Citations

[1]Wang K, et al. Discovery of novel phenyl urea SHP2 inhibitors with anti-colon cancer and potential immunomodulatory effects. Eur J Med Chem. 2025 Jan 5;281:117036.