MSAB

MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin and promotes its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells[1].

Product Specifications

CAS Number

[173436-66-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Wnt; β-catenin

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/msab.html

Purity

99.77

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC(NS(=O)(C2=CC=C(C=C2)C)=O)=C1)OC

Molecular Formula

C15H15NO4S

Molecular Weight

305.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Hwang SY, et, al. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling. Cell Rep. 2016 Jun 28;16 (1) :28-36.