NPD926
NPD926 is a small molecule that targets glutathione and induces cancer cell death. The Xc- system and glutathione are therapeutic targets in cancer. NPD926 causes cellular glutathione depletion and subsequent generation of reactive oxygen species (ROS), thereby sensitizing fibroblasts to Xc- system inhibitors. NPD926 is a ROS inducer with anticancer activity.[1].
Product Specifications
CAS Number
384361-79-9
UNSPSC
12352005
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/npd926.html
Smiles
CC(OC1=CC=C(C=C1)C(C2=CC=CC=C2)CCN(CC3=CC=C(C=C3)N(C)C)C(CCl)=O)C
Molecular Formula
C29H35ClN2O2
Molecular Weight
479.05
References & Citations
[1]A small molecule that induces reactive oxygen species via cellular glutathione depletion
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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