Nampt degrader-2

Nampt degrader-2 is a fluorescent PROTAC, which efficiently degrades NAMPT with an IC50 of 41.9 nM. Nampt degrader-2 binds to NAMPT and VHL to form a ternary complex and subsequently induced NAMPT degradation via ubiquitin-proteasome system (UPS) . Nampt degrader-2 leads to significant reduction of NAD+ and exerts potent antitumor activities[1].

Product Specifications

CAS Number

[3035008-40-0]

UNSPSC

12352005

Target

NAMPT; PROTACs

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nampt-degrader-2.html

Purity

99.41

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(C1=CC=C(C=C1)C(NCC2=CN=CC=C2)=O)=NC3=C4C=C(C=C3)NC(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)N4CCC

Molecular Formula

C59H73N9O7S

Molecular Weight

1052.33

References & Citations

[1]Junfei Cheng, et al. Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT. J Med Chem. 2022 Dec 8;65 (23) :15725-15737.