Tazobactam (sodium)
Tazobactam sodium is an antibiotic of the beta-lactamase inhibitor class. Ceftolozane combines with Tazobactam, extends the activity of ceftolozane against many ESBL-producing Enterobacteriaceae and some Bacteroides spp..
Product Specifications
CAS Number
89785-84-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/tazobactam-sodium.html
Purity
99.74
Solubility
DMSO : 200 mg/mL|H2O : 250 mg/mL (ultrasonic)
Smiles
C[C@]([C@@H](N1[C@@]2([H])CC1=O)C(O[Na])=O)([S]2(=O)=O)CN3C=CN=N3
Molecular Formula
C10H11N4NaO5S
Molecular Weight
322.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Giacobbe DR, et al. Ceftolozane/tazobactam: place in therapy. Expert Rev Anti Infect Ther. 2018;16 (4) :307‐320.|[2]Yang J, et al., Mechanisms of Piperacillin/Tazobactam Nephrotoxicity: Piperacillin/Tazobactam-Induced Direct Tubular Damage in Mice. Antibiotics (Basel) . 2023 Jun 28;12 (7) :1121.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
β-lactam
Citation 01
Antimicrob Agents Chemother. 2024 Nov 6;68 (11) :e0077524.|Eur J Clin Microbiol Infect Dis. 2025 Mar;44 (3) :571-585.|medRxiv. 2025 Mar 13:2025.03.11.25323422.|Nat Commun. 2022 Mar 2;13 (1) :1116.|ACS Environ Au. 2025 Aug 8.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Antimicrob Agents Chemother. 2023 Jun 15;67 (6) :e0160322.|bioRxiv. 2024 May 10.|Eur J Clin Microbiol Infect Dis. 2025 Feb;44 (2) :277-284.|Int J Antimicrob Agents. 2025 Jun 9:107551.|Int J Med Microbiol. 2021 Oct;70 (10) .|J Antimicrob Chemother. 2025 Nov 5:dkaf408.|Microbiol Spectr. 2023 Feb 14;11 (1) :e0303822.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0069223.|Molecules. 2025 Mar 9;30 (6) :1224.|PLoS Pathog. 2024 Dec 31;20 (12) :e1012783.|Research Square Preprint. 2021 Aug.
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