Tazobactam (sodium)

Tazobactam sodium is an antibiotic of the beta-lactamase inhibitor class. Ceftolozane combines with Tazobactam, extends the activity of ceftolozane against many ESBL-producing Enterobacteriaceae and some Bacteroides spp..

Product Specifications

CAS Number

[89785-84-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/tazobactam-sodium.html

Purity

99.74

Solubility

DMSO : 200 mg/mL|H2O : 250 mg/mL (ultrasonic)

Smiles

C[C@]([C@@H](N1[C@@]2([H])CC1=O)C(O[Na])=O)([S]2(=O)=O)CN3C=CN=N3

Molecular Formula

C10H11N4NaO5S

Molecular Weight

322.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Giacobbe DR, et al. Ceftolozane/tazobactam: place in therapy. Expert Rev Anti Infect Ther. 2018;16 (4) :307‐320.|[2]Yang J, et al., Mechanisms of Piperacillin/Tazobactam Nephrotoxicity: Piperacillin/Tazobactam-Induced Direct Tubular Damage in Mice. Antibiotics (Basel) . 2023 Jun 28;12 (7) :1121.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

β-lactam

Citation 01

Antimicrob Agents Chemother. 2024 Nov 6;68 (11) :e0077524.|Eur J Clin Microbiol Infect Dis. 2025 Mar;44 (3) :571-585.|medRxiv. 2025 Mar 13:2025.03.11.25323422.|Nat Commun. 2022 Mar 2;13 (1) :1116.|ACS Environ Au. 2025 Aug 8.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Antimicrob Agents Chemother. 2023 Jun 15;67 (6) :e0160322.|bioRxiv. 2024 May 10.|Eur J Clin Microbiol Infect Dis. 2025 Feb;44 (2) :277-284.|Int J Antimicrob Agents. 2025 Jun 9:107551.|Int J Med Microbiol. 2021 Oct;70 (10) .|J Antimicrob Chemother. 2025 Nov 5:dkaf408.|Microbiol Spectr. 2023 Feb 14;11 (1) :e0303822.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0069223.|Molecules. 2025 Mar 9;30 (6) :1224.|PLoS Pathog. 2024 Dec 31;20 (12) :e1012783.|Research Square Preprint. 2021 Aug.