Asterric Acid
Asterric acid is an antibiotic fungal metabolite that completely inhibits the binding of the potent vasoconstrictor endothelin (ET) -1 to the ETA receptor in A10 cells at 0.1 μM.1 Asterric acid derivatives have also been shown to inhibit VEGF-induced tube formation of human umbilical vein endothelial cells at 3-10 μM, which suggests its usefulness as an antiangiogenic agent.
Product Specifications
CAS Number
[577-64-0]
Product Name Alternative
Dimethylosoic acid; RES-1214-1; TAN 1415A
UNSPSC
12352005
Hazard Statement
H410
Target
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/asterric-acid.html
Smiles
CC1=CC(O)=C(C(OC2=C(C=C(C=C2C(OC)=O)O)OC)=C1)C(O)=O
Molecular Formula
C17H16O8
Molecular Weight
348.30
Precautions
P273-P391-P501
References & Citations
[1]Ohashi, et al. Asterric acid, a new endothelin binding inhibitor. J. Antibiot. (Tokyo) 45, 1684-1685 (1992) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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