Mouse anti Human p21 WAF-1
Product Specifications
Background
The p21waf1 tumor suppressor protein shows no cross reactivity with the closely related inhibitors .p21waf1 is a specific inhibitor of cdkÕs, and is a tumor suppressor involved in the pathogenesis of a number of malignancies including colon and breast carcinoma
Synonyms
p21waf1, hp21, Cyclin-dependent kinase inhibitor 1, CDK-interacting Protein 1, Melanoma differentiation-associated Protein 6
UniProt
P38936 (Human)
Host
Mouse
Species Reactivity
Human
Isotype
IgG2a
Clone
DCS-60
Conjugation
Unconjugated
Type
Monoclonal Antibody
Source
Mice were immunized with a recombinant full length p21 protein.
Applications
WB, IP, IHC
Field of Research
Cell Cycle
Purification Method
Protein A/G Chromatography
Assay Principle
1-5 µg /mL for Western Blot, Immunoflurescence, Immunoprecipitation (co-precipitates cdk4/cdk6)
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1) R. Erber, et.al. (1997) Pred. Oncol. 74, 383-389 _x000D_
2. Shen, J., et al. ‘Identification and Validation of Differences in Protein Levels in Normal, Premalignant, and Malignant Lung Cells and Tissues Using High-Throughput Western Array and Immunohistochemistry.’ Cancer Res., 66, 11194-11206 (2006).
Shipping Conditions
Ambient Temperature
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB
CAS Number
9007-83-4
Curated Selection
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