L 748780
L 748780 (compound 2) is a selectivity COX-2 inhibitor with the IC50 values of 0.5 μM and > 100 μM for COX-2 and COX-1, respectively[1].
Product Specifications
CAS Number
168086-64-4
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/l-748780.html
Smiles
O=C(CC1=C(C)N(C(C2=C(Cl)C=C(Cl)C=C2Cl)=O)C3=C1C=C(C=C3)OC)O
Molecular Formula
C19H14Cl3NO4
Molecular Weight
426.68
References & Citations
[1]Lau CK, et al. From indomethacin to a selective COX-2 inhibitor. Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors. Adv Exp Med Biol. 1997;407:73-8. PMID: 9321934.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
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