Pelacarsen (sodium)

Pelacarsen sodium (ISIS 681257 sodium) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen sodium reduces apo (a) [1][2][3].

Product Specifications

CAS Number

[2172851-58-8]

Product Name Alternative

AKCEA-APO (a) -LRx (sodium) ; ISIS 681257 (sodium) ; TQJ230 (sodium)

UNSPSC

12352208

Target

Apolipoprotein; DNA/RNA Synthesis

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pelacarsen-sodium.html

Purity

92.70

Solubility

10 mM in H2O

Smiles

[Pelacarsen(sodium)]

Molecular Formula

C296H419N71Na20O163P20S13

Molecular Weight

8636 (free acid)

References & Citations

[1]Yeang C, et al. Effect of Pelacarsen on Lipoprotein (a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol. J Am Coll Cardiol. 2022 Mar 22;79 (11) :1035-1046. |[2]Yu RZ, Graham MJ, Post N, et al. Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice. Mol Ther Nucleic Acids. 2016;5 (5) :e317. |[3]Yu RZ, Gunawan R, Post N, et al. Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys. Nucleic Acid Ther. 2016;26 (6) :372-380.