Pelacarsen (sodium)
Pelacarsen sodium (ISIS 681257 sodium) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen sodium reduces apo (a) [1][2][3].
Product Specifications
CAS Number
[2172851-58-8]
Product Name Alternative
AKCEA-APO (a) -LRx (sodium) ; ISIS 681257 (sodium) ; TQJ230 (sodium)
UNSPSC
12352208
Target
Apolipoprotein; DNA/RNA Synthesis
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pelacarsen-sodium.html
Purity
92.70
Solubility
10 mM in H2O
Smiles
[Pelacarsen(sodium)]
Molecular Formula
C296H419N71Na20O163P20S13
Molecular Weight
8636 (free acid)
References & Citations
[1]Yeang C, et al. Effect of Pelacarsen on Lipoprotein (a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol. J Am Coll Cardiol. 2022 Mar 22;79 (11) :1035-1046. |[2]Yu RZ, Graham MJ, Post N, et al. Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice. Mol Ther Nucleic Acids. 2016;5 (5) :e317. |[3]Yu RZ, Gunawan R, Post N, et al. Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys. Nucleic Acid Ther. 2016;26 (6) :372-380.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
