Mouse anti Human p107
Product Specifications
Background
P107 is related both in structure and function to the retinoblastoma tumor suppressor protein and p130 (collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p107 converts E2F transcription factors from transcriptional activators to transcriptional repressors.
Synonyms
p107, Retinoblastoma-like Protein 1, PRB1, 107 kda retinoblastoma-associated Protein
UniProt
P28749 (Human), Q64701 (Mouse)
Host
Mouse
Species Reactivity
Human,Mouse,Rat
Isotype
IgG1
Clone
KAB6
Conjugation
Unconjugated
Type
Monoclonal Antibody
Source
The immunogen used to immunize the mice was a recombinant GST protein coupled to the N-terminus of p107.
Applications
WB
Field of Research
Cell Cycle
Purification Method
Protein A/G Chromatography
Assay Principle
Western Blots at 1:1000
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
KAB6 recognizes both the phosphorylated and unphosphorylated forms of p107 at a MW of 107kDa., Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
Shipping Conditions
Ambient Temperature
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB
CAS Number
9007-83-4
Curated Selection
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