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Mouse anti Human p107

Product Specifications

Background

P107 is related both in structure and function to the retinoblastoma tumor suppressor protein and p130 (collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p107 converts E2F transcription factors from transcriptional activators to transcriptional repressors.

CAS Number

9007-83-4

Synonyms

p107, Retinoblastoma-like Protein 1, PRB1, 107 kda retinoblastoma-associated Protein

UniProt

P28749 (Human), Q64701 (Mouse)

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Isotype

IgG1

Clone

KAB6

Conjugation

Unconjugated

Type

Monoclonal Antibody

Source

The immunogen used to immunize the mice was a recombinant GST protein coupled to the N-terminus of p107.

Applications

WB

Field of Research

Cell Cycle

Purification Method

Protein A/G Chromatography

Assay Principle

Western Blots at 1:1000

Stability

See expiration date on vial

Concentration

See vial for Concentration

Form

KAB6 recognizes both the phosphorylated and unphosphorylated forms of p107 at a MW of 107kDa., Provided as solution in phosphate buffered saline with 0,08% sodium azide

Precautions

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

Shipping Conditions

Ambient Temperature

Storage Conditions

Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

Functional Analysis

WB

Frequently Asked Questions

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