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VU0155041

VU0155041 is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD) [1].

Product Specifications

CAS Number

1093757-42-6

UNSPSC

12352005

Hazard Statement

H302

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0155041.html

Purity

99.10

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H](CCCC1)[C@H]1C(O)=O)NC2=CC(Cl)=CC(Cl)=C2

Molecular Formula

C14H15Cl2NO3

Molecular Weight

316.18

Precautions

P264-P270-P330-P501

References & Citations

[1]Niswender CM, et, al. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol. 2008 Nov; 74 (5) : 1345-58.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MGluR4

Available Sizes

Frequently Asked Questions

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