TL8-506
TL8-506 is a specific TLR8 agonist with an EC50 of 30 nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy[1][2].
Product Specifications
CAS Number
[1268163-15-0]
UNSPSC
12352005
Target
Bacterial; Interleukin Related; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tl8-506.html
Concentration
10mM
Purity
95.0
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=CC=C(C3=CC=CC(C#N)=C3)C=C2N=C(N)C1)OCC
Molecular Formula
C20H17N3O2
Molecular Weight
331.37
References & Citations
[1]Jun Tang, et al. Toll-Like Receptor 8 Agonist Strengthens the Protective Efficacy of ESAT-6 Immunization to Mycobacterium tuberculosis Infection. Front Immunol. 2018 Jan 24;8:1972. |[2]He M, S, et al. Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells. J Immunother Cancer. 2022 Jun;10 (6) :e004268.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR8
Available Sizes
Curated Selection
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