Epolactaene

Epolactaene is a potent Topoisomerase II and DNA Polymerase inhibitor with IC50 values of 10, 25, 94 µM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively[1].

Product Specifications

CAS Number

[167782-17-4]

UNSPSC

12352005

Target

DNA/RNA Synthesis; Topoisomerase

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/epolactaene.html

Smiles

COC(C(/C=C(C)/C=C/CC/C=C(C)/C([C@@]12[C@@](C(O)(NC2=O)C)([H])O1)=O)=C/C)=O

Molecular Formula

C21H27NO6

Molecular Weight

389.44

References & Citations

[1]Mizushina Y, et al. Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, selectively inhibits the activities of mammalian DNA polymerases and human DNA topoisomerase II. Biochem Biophys Res Commun. 2000 Jul 5;273 (2) :784-8.