Vecuronium (bromide)

Vecuronium (ORG NC 45) bromide is a non-depolarizing neuromuscular blocking agent that also acts as a nicotinic acetylcholine receptor (nAChR) inhibitor, a muscle relaxant, and can be used for pre-surgical anesthesia[1][2].

Product Specifications

CAS Number

[50700-72-6]

Product Name Alternative

ORG NC 45

UNSPSC

12352005

Hazard Statement

H302

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vecuronium-bromide.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 83.33 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

C[C@@]1([C@H]2OC(C)=O)[C@](C[C@@H]2[N+]3(CCCCC3)C)([H])[C@@](CC[C@]4([H])[C@@]5(C[C@H](N6CCCCC6)[C@@H](OC(C)=O)C4)C)([H])[C@]5([H])CC1.[Br-]

Molecular Formula

C34H57BrN2O4

Molecular Weight

637.73

Precautions

H302

References & Citations

[1]Meretoja, O.A., Vecuronium infusion requirements in pediatric patients during fentanyl-N2O-O2 anesthesia. Anesth Analg, 1989. 68 (1) : p. 20-4.|[2]Agoston, S., et al., The neuromuscular blocking action of ORG NC 45, a new pancuronium derivative, in anaesthetized patients. A pilot study. Br J Anaesth, 1980. 52 Suppl 1: p. 53S-59S.|[3]Shingu, K., et al., [Neuromuscular blocking effects of Org 9426 (rocuronium bromide) ; a comparative study with vecuronium bromide in Japanese patients]. Masui, 2006. 55 (9) : p. 1140-8.|[4]K Uryu, et al. Inhibition by neuromuscular blocking drugs of norepinephrine transporter in cultured bovine adrenal medullary cells. Anesth Analg. 2000 Sep;91 (3) :546-51.|[5]Iddrisu BabaYabasin, et al. Anticancer effects of vecuronium bromide and cisatracurium besylate on lung cancer cells (A549), in vitro. Biomedicine & Aging Pathology, Volume 4, Issue 4, |[6]Ayuko Igarashi, et al. Vecuronium directly inhibits hypoxic neurotransmission of the rat carotid body. Anesth Analg. 2002 Jan;94 (1) :117-22, table of contents.