AF40431

AF40431, the first reported small-molecule ligand of sortilin, has an IC50 of 4.4 µM and a Kd of 0.7 µM . AF40431 is bound in the neurotensin-binding site of sortilin[1].

Product Specifications

CAS Number

181125-92-8

UNSPSC

12352005

Target

Neurotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/af40431.html

Purity

98.09

Solubility

DMSO : 25 mg/mL (ultrasonic; adjust pH to 1 with TFA)

Smiles

CC(C)C[C@@H](C(O)=O)NCC1=C(O2)C(C(C)=CC2=O)=CC=C1O

Molecular Formula

C17H21NO5

Molecular Weight

319.35

References & Citations

[1]Andersen JL, et al. Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70 (Pt 2) :451-60.