10'-Desmethoxystreptonigrin
10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an IC50 of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD50 is 8.8 mg/kg) [1].
Product Specifications
CAS Number
136803-89-9
UNSPSC
12352005
Target
Antibiotic; Bacterial; Farnesyl Transferase
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/10-desmethoxystreptonigrin.html
Smiles
NC(C(C(C=CC=C1OC)=C1O)=C2C)=C(C3=CC=C(C4=O)C(C(C(N)=C4OC)=O)=N3)N=C2C(O)=O
Molecular Formula
C24H20N4O7
Molecular Weight
476.44
References & Citations
[1]Liu WC, et al. 10'-Desmethoxystreptonigrin, a novel analog of streptonigrin. J Antibiot (Tokyo) . 1992 Apr;45 (4) :454-7.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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