Loperamide oxide
Loperamide oxide (R-58425) is a orally active prodrug of the Loperamide. Loperamide oxide incubation with the contents of the intestinal lumen inhibits fluid secretion under aerobic conditions[1][2].
Product Specifications
CAS Number
106900-12-3
Product Name Alternative
R-58425
UNSPSC
12352005
Hazard Statement
H301
Target
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/loperamide-oxide.html
Smiles
O=C(C(C1=CC=CC=C1)(CC[N@+]2(CC[C@](C3=CC=C(C=C3)Cl)(CC2)O)[O-])C4=CC=CC=C4)N(C)C
Molecular Formula
C29H33ClN2O3
Molecular Weight
493.04
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Hardcastle J, et al. The effect of loperamide oxide on prostaglandin-stimulated fluid transport in rat small intestine. J Pharm Pharmacol. 1990;42 (5) :364-366. |[2]Kamali F, Huang ML. Increased systemic availability of loperamide after oral administration of loperamide and loperamide oxide with cotrimoxazole. Br J Clin Pharmacol. 1996;41 (2) :125-128.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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