N-Desethyl amodiaquine

N-Desethyl amodiaquine is the biologically active metabolite of Amodiaquine (HY-B1322A) . N-Desethyl amodiaquine is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine can be used for the research of malaria[1][2].

Product Specifications

CAS Number

[79352-78-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/n-desethyl-amodiaquine.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1CNCC

Molecular Formula

C18H18ClN3O

Molecular Weight

327.81

Precautions

H302, H315, H319, H335

References & Citations

[1]Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199 (11) :1575-82.|[2]Xue-Qing Li, et al. Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300 (2) :399-407.