Anti-Mouse Jagged 2 Antibody (HMJ2-1)

Anti-Mouse Jagged 2 Antibody (HMJ2-1) is an anti-mouse Jagged 2 IgG monoclonal antibody. Anti-Mouse Jagged 2 Antibody (HMJ2-1) regulates Treg/Th17 balance through IL-9. Anti-Mouse Jagged 2 Antibody (HMJ2-1) increases Jagged2-Notch signaling through activation of RBP-Jk. Anti-Mouse Jagged 2 Antibody (HMJ2-1) can be used for researches on inflammation conditions and xenotransplantation such as experimental autoimmune encephalomyelitis (EAE) [1][2][3][4].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352203

Target

Interleukin Related; Notch

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation; Neuronal Signaling; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-jagged-2-antibody-hmj2-1.html

Solubility

10 mM in DMSO

Smiles

[Anti-MouseJagged2Antibody(HMJ2-1)]

Molecular Weight

(150 kDa)

References & Citations

[1]Sekine C, et al. Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes. Arthritis Res Ther. 2012 Mar 5;14 (2) :R45.|[2]Martinez-Lozada Z, et al. Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression. Neurochem Int. 2020 Oct;139:104787.|[3]Elyaman W, et al. Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. Immunity. 2012 Apr 20;36 (4) :623-34.|[4]Riella LV, et al. Jagged2-signaling promotes IL-6-dependent transplant rejection. Eur J Immunol. 2013 Jun;43 (6) :1449-58.