TOFA
TOFA (RMI14514; MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA) .
Product Specifications
CAS Number
54857-86-2
Product Name Alternative
RMI14514; MDL14514
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Acetyl-CoA Carboxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TOFA.html
Purity
99.91
Solubility
DMSO : 11.36 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(OCCCCCCCCCCCCCC)O1)O
Molecular Formula
C19H32O4
Molecular Weight
324.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang C, et al. Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis. Biochem Biophys Res Commun. 2009 Jul 31;385 (3) :302-6.|[2]Li S, et al. TOFA suppresses ovarian cancer cell growth in vitro and in vivo. Mol Med Rep. 2013 Aug;8 (2) :373-8.|[3]Guseva NV, et al. TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status. Cancer Biol Ther. 2011 Jul 1;12 (1) :80-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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