TOFA

TOFA (RMI14514; MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA) .

Product Specifications

CAS Number

[54857-86-2]

Product Name Alternative

RMI14514; MDL14514

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Acetyl-CoA Carboxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/TOFA.html

Purity

99.91

Solubility

DMSO : 11.36 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(OCCCCCCCCCCCCCC)O1)O

Molecular Formula

C19H32O4

Molecular Weight

324.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang C, et al. Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis. Biochem Biophys Res Commun. 2009 Jul 31;385 (3) :302-6.|[2]Li S, et al. TOFA suppresses ovarian cancer cell growth in vitro and in vivo. Mol Med Rep. 2013 Aug;8 (2) :373-8.|[3]Guseva NV, et al. TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status. Cancer Biol Ther. 2011 Jul 1;12 (1) :80-5.