(25S) -Δ7-Dafachronic acid

(25S) -Δ7-Dafachronic acid is a ligand and activator of DAF-12 receptor. DAF-12 is a nuclear hormone receptor that regulates larval diapause, developmental age, and adult longevity in Caenorhabditis elegans[1][2][3].

Product Specifications

CAS Number

[949004-12-0]

Product Name Alternative

Dafachronic acid A; Δ7-Dafachronic acid

UNSPSC

12352211

Target

Insecticide

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/25s-7-dafachronic-acid.html

Purity

95.40

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC[C@H](C)C(O)=O)([H])C3=CC[C@](CC(CC4)=O)([H])[C@@]4(C)[C@@]3([H])CC1

Molecular Formula

C27H42O3

Molecular Weight

414.62

References & Citations

[1]|[2]Martin R, et al. Stereoselective synthesis of the hormonally active (25S) -delta7-dafachronic acid, (25S) -Delta4-dafachronic acid, (25S) -dafachronic acid, and (25S) -cholestenoic acid. Org Biomol Chem. 2008 Dec 7;6 (23) :4293-5. |[3]Sharma KK, et al. Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Mol Endocrinol. 2009 May;23 (5) :640-8. |[4]Ma G, et al. Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism. PLoS Pathog. 2019 Jul 23;15 (7) :e1007960.