HB-3-20
Product Specifications
UNSPSC Description
HB-3-20 leads to degradation of the cell surface integrin αVβ5. Transglutaminase 2 (TG2) has specificity for HB-3-20 (kcat/KM=0.16 μM-1min-1)[1].
Target Antigen
Integrin
Type
Peptides
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hb-3-20.html
Smiles
O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CC2=CC=CC=C2)C(NCC(NCC(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=CC=C3)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]4N(C(C)=O)CCC4
Molecular Weight
1531.67
References & Citations
[1]Elise Loppinet, et al. Targeted Lysosomal Degradation of Secreted and Cell Surface Proteins through the LRP-1 Pathway. J Am Chem Soc. 2023 Aug 30;145(34):18705-18710.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P10677/HB-3-20-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P10677/
Clinical Information
No Development Reported
Curated Selection
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