N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.
Product Specifications
CAS Number
[4272-74-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Amino Acid Derivatives
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride.html
Purity
99.0
Solubility
DMSO : ≥ 100 mg/mL|H2O : ≥ 100 mg/mL
Smiles
O=S(C1=CC=C(C)C=C1)(N[C@H](C(CCl)=O)CCCCN)=O.Cl
Molecular Formula
C14H22Cl2N2O3S
Molecular Weight
369.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Shadrin N, et al. Serine protease inhibitors interact with IFN-γ through up-regulation of FasR; a novel therapeutic strategy against cancer. Exp Cell Res. 2015 Jan 15;330 (2) :233-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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