Raphin1
Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B) . Raphin1 binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease[1].
Product Specifications
CAS Number
2022961-17-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/raphin1.html
Purity
99.75
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N=C(N/N=C/C1=CC=CC(Cl)=C1Cl)N
Molecular Formula
C8H8Cl2N4
Molecular Weight
231.08
Precautions
H302, H315, H319, H335
References & Citations
[1]Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174 (5) :1216-1228.e19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Nat Commun. 2024 Aug 9;15 (1) :6810.|bioRxiv. 2024 Feb 5.|Nature. 2023 Sep;621 (7977) :188-195.
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