Loperamide oxide (Standard)

Loperamide oxide (Standard) is the analytical standard of Loperamide oxide. This product is intended for research and analytical applications. Loperamide oxide (R-58425) is a orally active prodrug of the Loperamide (HY-156131) . Loperamide oxide incubation with the contents of the intestinal lumen inhibits fluid secretion under aerobic conditions[1][2].

Product Specifications

CAS Number

[106900-12-3]

Product Name Alternative

R-58425 (Standard)

UNSPSC

12352005

Target

Opioid Receptor; Reference Standards

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/loperamide-oxide-standard.html

Smiles

O=C(C(C1=CC=CC=C1)(CC[N@+]2(CC[C@](C3=CC=C(C=C3)Cl)(CC2)O)[O-])C4=CC=CC=C4)N(C)C

Molecular Formula

C29H33ClN2O3

Molecular Weight

493.04

References & Citations

[1]Hardcastle J, et al. The effect of loperamide oxide on prostaglandin-stimulated fluid transport in rat small intestine. J Pharm Pharmacol. 1990;42 (5) :364-366. |[2]Kamali F, Huang ML. Increased systemic availability of loperamide after oral administration of loperamide and loperamide oxide with cotrimoxazole. Br J Clin Pharmacol. 1996;41 (2) :125-128.