Diazoxide
Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.
Product Specifications
CAS Number
364-98-7
Product Name Alternative
Sch-6783; SRG-95213
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H350, H360
Target
Autophagy; Potassium Channel
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Diazoxide.html
Concentration
10mM
Purity
99.99
Solubility
DMSO : ≥ 35 mg/mL
Smiles
CC(NC1=CC=C(Cl)C=C12)=NS2(=O)=O
Molecular Formula
C8H7ClN2O2S
Molecular Weight
230.67
Precautions
H302, H315, H319, H335, H350, H360
References & Citations
[1]Coetzee WA, et al. Multiplicity of effectors of the cardioprotective agent, diazoxide. Pharmacol Ther. 2013 Nov;140 (2) :167-75.|[2]Virgili N, et al. K (ATP) channel opener diazoxide prevents neurodegeneration: a new mechanism of action viaantioxidative pathway activation. PLoS One. 2013 Sep 11;8 (9) :e75189.|[3]Wu H, et al. Diazoxide Attenuates Postresuscitation Brain Injury in a Rat Model of Asphyxial Cardiac Arrest by Opening Mitochondrial ATP-Sensitive Potassium Channels. Biomed Res Int. 2016;2016:1253842.|[4]Chowdhury UR, et al. ATP-sensitive potassium (K (ATP) ) channel openers diazoxide and nicorandil lower intraocular pressure in vivo. Invest Ophthalmol Vis Sci. 2013 Jul 22;54 (7) :4892-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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