Thrombin from Human Plasma (High Activity)

<strong>Thrombin from Human Plasma (High Activity)</strong>_x000D_ <strong>Catalog number:</strong> B2010413_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 Units_x000D_ <strong>Molecular Weight or Concentration:</strong> ‚â•2,000 NIH units/mg protein_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> very high specific activity Thrombin from human plasma. Thrombin is a serin protease that converts soluble fibrinogen into insoluble fibrin during the clotting process. Activity is measured using the NIH Thrombin Reference Standard._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> Factor Iia, Bovine Thrombin, fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin_x000D_ <strong>Grade:</strong> Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Hemker HC, Al Dieri R, B√©guin S. Thrombin generation assays: accruing_x000D_ clinical relevance. Curr Opin Hematol. 2004 May;11(3):170-5._x000D_ _x000D_ 2: Bode W. The structure of thrombin: a janus-headed proteinase. Semin Thromb_x000D_ Hemost. 2006 Apr;32 Suppl 1:16-31._x000D_ _x000D_ 3: Xiao J , Salsbury FR . Na⁺-binding modes involved in thrombin's_x000D_ allosteric response as revealed by molecular dynamics simulations, correlation_x000D_ networks and Markov modeling. Phys Chem Chem Phys. 2019 Feb 20;21(8):4320-4330._x000D_ _x000D_ 4: Li X, Wu Y, Niu J, Jiang D, Xiao D, Zhou C. One-step sensitive thrombin_x000D_ detection based on a nanofibrous sensing platform. J Mater Chem B. 2019 Sep_x000D_ 14;7(34):5161-5169._x000D_ _x000D_ 5: Chan B, Merchan JR, Kale S, Sukhatme VP. Antiangiogenic property of human_x000D_ thrombin. Microvasc Res. 2003 Jul;66(1):1-14._x000D_ _x000D_ 6: Gordon EA, Fenton JW 2nd, Carney DH. Thrombin-receptor occupancy initiates a_x000D_ transient increase in cAMP levels in mitogenically responsive hamster (NIL)_x000D_ fibroblasts. Ann N Y Acad Sci. 1986;485:249-63._x000D_ _x000D_ 7: Festoff BW, Smirnova IV, Ma J, Citron BA. Thrombin, its receptor and protease_x000D_ nexin I, its potent serpin, in the nervous system. Semin Thromb Hemost._x000D_ 1996;22(3):267-71._x000D_ _x000D_ 8: Anderson CD, Bowman LJ, Chapman WC. Topical use of recombinant human thrombin_x000D_ for operative hemostasis. Expert Opin Biol Ther. 2009 Jan;9(1):133-7._x000D_ _x000D_ 9: Tanaka KA, Levy JH. Regulation of thrombin activity--pharmacologic and_x000D_ structural aspects. Hematol Oncol Clin North Am. 2007 Feb;21(1):33-50._x000D_ _x000D_ 10: Leung LL, Myles T, Nishimura T, Song JJ, Robinson WH. Regulation of tissue_x000D_ inflammation by thrombin-activatable carboxypeptidase B (or TAFI). Mol Immunol._x000D_ 2008 Oct;45(16):4080-3._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/32278295/">11: Xu H, Cui H, Yin Z, Wei G, Liao F, Shu Q, Ma G, Cheng L, Hong N, Xiong J,_x000D_ Fan H. Highly sensitive host-guest mode homogenous electrochemical thrombin_x000D_ signal amplification aptasensor based on tetraferrocene label._x000D_ Bioelectrochemistry. 2020 Aug;134:107522. </a>_x000D_ _x000D_ <strong>Products Related to Thrombin from Human Plasma (High Activity)</strong><a href="https://moleculardepot.com/product-category/Enzymes/">: Enzymes</a>