9 (S) -PAHSA

9 (S) -PAHSA is a S-enantiomer of 9-PAHSA. 9-PAHSA is an orally available anti-inflammatory lipid that lowers blood sugar and reduces inflammation[1][2].

Product Specifications

CAS Number

[2097130-87-3]

UNSPSC

12352211

Hazard Statement

H225-H319-H336

Target

Drug Isomer; NF-κB

Type

Reference compound

Related Pathways

NF-κB; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/9-s-pahsa.html

Solubility

10 mM in DMSO

Smiles

CCCCCCCCC[C@H](OC(CCCCCCCCCCCCCCC)=O)CCCCCCCC(O)=O

Molecular Formula

C34H66O4

Molecular Weight

538.89

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Nelson AT, et al. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. J Am Chem Soc. 2017 Apr 5;139 (13) :4943-4947. |[2]Wang YM, et al. 9-PAHSA Improves Cardiovascular Complications by Promoting Autophagic Flux and Reducing Myocardial Hypertrophy in Db/Db Mice. Front Pharmacol. 2021 Nov 15;12:754387.|[3]Wang YM, et al. 9-PAHSA promotes browning of white fat via activating G-protein-coupled receptor 120 and inhibiting lipopolysaccharide / NF-kappa B pathway. Biochem Biophys Res Commun. 2018 Nov 17;506 (1) :153-160.