(R) -3-O-Methyldopa-d3 (hydrochloride)
(R) -3-O-Methyldopa-d3 (hydrochloride) is a deuterium labeled (R) -3-O-Methyldopa, and (R) -3-O-Methyldopa is an R-enantiomer of 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT) . 3-O-Methyldopa competitively inhibits the pharmacodynamics of L-DOPA and dopamine[1][2].
Product Specifications
CAS Number
2714485-35-3
UNSPSC
12352005
Target
Dopamine Receptor; Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
OC([C@H](N)CC1=CC(OC([2H])([2H])[2H])=C(C=C1)O)=O.Cl
Molecular Formula
C10H11D3ClNO4
Molecular Weight
250.69
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Asanuma M, Miyazaki I. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA. BMC Neurosci. 2016 Jul 25;17 (1) :52.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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