Friedelin
Friedelin is derived from the leaves of Maytenus ilicifolia (Mart) . Friedelin is an orally active non-competitive inhibitor of CYP3A4, with IC50 and Ki values of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1, with IC50 and Ki values of 22.54 μM and 18.02 μM, respectively. Friedelin can be used in research related to inflammation, neurological diseases, and metabolic disorders[1][2][3][4].
Product Specifications
CAS Number
559-74-0
UNSPSC
12352211
Hazard Statement
H315, H319
Target
Cytochrome P450; Interleukin Related; NF-κB
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/friedelin.html
Purity
99.0
Solubility
THF : 8.33 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@]([C@@]3([H])[C@](C)(CCC(C)(C)C3)CC1)(CC[C@]4(C)[C@]2([H])CC[C@@]([C@H]5C)(C)[C@@]4([H])CCC5=O)C
Molecular Formula
C30H50O
Molecular Weight
426.72
Precautions
H315, H319
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP2; CYP3
Available Sizes
Frequently Asked Questions
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