Friedelin

Friedelin is derived from the leaves of Maytenus ilicifolia (Mart) . Friedelin is an orally active non-competitive inhibitor of CYP3A4, with IC50 and Ki values of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1, with IC50 and Ki values of 22.54 μM and 18.02 μM, respectively. Friedelin can be used in research related to inflammation, neurological diseases, and metabolic disorders[1][2][3][4].

Product Specifications

CAS Number

[559-74-0]

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Cytochrome P450; Interleukin Related; NF-κB

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/friedelin.html

Purity

99.0

Solubility

THF : 8.33 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]([C@@]3([H])[C@](C)(CCC(C)(C)C3)CC1)(CC[C@]4(C)[C@]2([H])CC[C@@]([C@H]5C)(C)[C@@]4([H])CCC5=O)C

Molecular Formula

C30H50O

Molecular Weight

426.72

Precautions

H315, H319

References & Citations

[1]Wei J, et al. In vitro inhibitory effects of Friedelin on human liver cytochrome P450 enzymes. Pharm Biol. 2018 Dec;56 (1) :363-367.|[2]Antonisamy P, et al. Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models. J Pharm Pharmacol. 2011 Aug;63 (8) :1070-7.|[3]Sandhu M, et al. Friedelin Attenuates Neuronal Dysfunction and Memory Impairment by Inhibition of the Activated JNK/NF-κB Signalling Pathway in Scopolamine-Induced Mice Model of Neurodegeneration. Molecules. 2022 Jul 14;27 (14) :4513.|[4]Jiang H, et al. Friedelin Alleviates the Pathogenesis of Collagenase-Induced Tendinopathy in Mice by Promoting the Selective Autophagic Degradation of p65. Nutrients. 2022 Apr 18;14 (8) :1673.