Isomangiferin

Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290) . Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1) . Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing[1][2][3][4][5].

Product Specifications

CAS Number

[24699-16-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Acetyl-CoA Carboxylase; AMPK; Apoptosis; Bacterial; HSV; NF-κB; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS) ; VEGFR

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Isomangiferin.html

Concentration

10mM

Purity

99.60

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=CC(O)=C2C(OC3=CC(O)=C(O)C=C3C2=O)=C1[C@@H]([C@@H]([C@@H](O)[C@@H]4O)O)O[C@@H]4CO

Molecular Formula

C19H18O11

Molecular Weight

422.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Zheng MS, et al. Antiviral effect of mangiferin and isomangiferin on herpes simplex virus. Chin Med J (Engl) . 1990 Feb;103 (2) :160-5.|[2]Gao B, et al. Isomangiferin promotes the migration and osteogenic differentiation of rat bone marrow mesenchymal stem cells. Open Life Sci. 2024 Jul 20;19 (1) :20220884. doi: 10.1515/biol-2022-0884. PMID: 39035458; PMCID: PMC11259999.|[3]Yue S, et al. Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation. Diabetes Metab Syndr Obes. 2020 Nov 10;13:4273-4280. |[4]Wang B, et al. Isomangiferin, a Novel Potent Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor, Suppresses Breast Cancer Growth, Metastasis and Angiogenesis. J Breast Cancer. 2018 Mar;21 (1) :11-20. |[5]Ishaque M, et al. Xanthone C-glycosides isomers purified from Dryopteris ramosa (Hope) C. Chr. with bactericidal and cytotoxic prospects. Saudi J Biol Sci. 2022 Feb;29 (2) :1191-1196.